The investigators hypothesize that schoolchildren treated with IPT using DP over one year of follow-up will have a different risk of clinical malaria compared to those treated with placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
740
Given every 4 months (once a school term)
Given every month
No active ingredient
Mulanda Sub-district
Tororo, Uganda, Uganda
Risk of Clinical Malaria
Fever(temperature greater or equal to 37.5 degrees centigrade or history of fever in past 24 hours) in presence of parasitemia.
Time frame: 1 year
Cognitive function tests
Mean score in the cognitive function tests (Raven's Matrices test and Code transmission test)
Time frame: 1 year
Risk of parasitemia
presence of asexual parasites on blood smear
Time frame: 1 year
Risk of hospital admissions
Admission of any cause
Time frame: 1 year
Risk of adverse events
Any untoward medical occurrence in a participant taking study medication
Time frame: 1 year
School performance
Average position in class as reported in the end of the year school report
Time frame: 1 year
Prevalence of anemia
Proportion of hemoglobin measurements \< 10 g/dL.
Time frame: 1 year
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