Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting

Joseph Kim15 enrolled

Overview

The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Methicillin-resistant Staphylococcus Aureus

Interventions

pharmacological decolonization treatmentDRUG

Chlorhexidine gluconate 4% body scrub and 2% shampoo daily PLUS mupirocin 2%, fusidic acid 2%, or chlorhexidine gluconate 0.2% intranasally bid PLUS trimethoprim-sulfamethoxazole 160/800mg po bid or doxycycline 100mg po bid all for 7 days

EducationBEHAVIORAL

No pharmacological decolonization treatment but given education regarding personal hygiene and environmental cleaning

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Prior MRSA infection (i.e index case) * Identified as being colonized with MRSA on initial screen Exclusion Criteria: * Are pregnant or breastfeeding. * Have indwelling catheters. * Received prior decolonization treatment within last 6 months of enrollment. * Have allergy to study medication. * Are colonized with MRSA strain resistant to study medication. * Have active infection requiring systemic antimicrobials. * Are household contacts to index case.

Locations (1)

Foothills Medical Center

Calgary, Alberta, Canada

Outcomes

Primary Outcomes

Eradication of MRSA carriage

Time frame: 90 days after randomization

Secondary Outcomes

Occurrence of MRSA infection

Time frame: Within 6 months of randomization

Data from ClinicalTrials.gov

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