Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.

University Hospital, Gentofte, Copenhagen15 enrolled

Overview

Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss. Therefore we want to investigate mechanistic relations between the three hormones.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Incretin Action Obesity

Interventions

GLP-1 infusionOTHER

1 pmol/kg/min

Glucagon infusionOTHER

3ng/kg/min

Oxyntomodulin infusionOTHER

3 pmol/kg/min

GLP-1 and glucagon infusion

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal fasting plasma glucose * Normal glucose tolerance * Normal haemoglobin levels * Informed content Exclusion Criteria: * Diabetes * Pre diabetes (impaired glucose tolerance or impaired fasting glucose) * 1st degree relatives with diabetes * Obesity (BMI \> 30) * Inflammatory bowels disease * Bowels surgery * Nephropathy * Liver disease * Medication which cannot be on hold for 24h

Locations (1)

Gentofte University Hospital

Hellerup, Denmark

Outcomes

Primary Outcomes

Gastric emptying

Assessed by the acetaminophen - method

Time frame: 4 h

Satiety

Assessed by VAS

Time frame: 4 h

Hunger

Assessed by an ad'libitum meal

Time frame: 4 h

basal energy expenditure

Assessed by indirect calorimetry

Time frame: 2 x 30min

Secondary Outcomes

GLP-1

Time frame: 4 h

Oxyntomodulin

Time frame: 4 h

Glucagon

Time frame: 4 h

GIP

Time frame: 4 h

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.