A Study of Brain Receptor Occupancy in Healthy Subjects

Inclusion Criteria: * Healthy male or female * Have clinical laboratory tests within normal reference ranges * Have arterial and venous access sufficient to allow blood sampling Exclusion Criteria: * Currently enrolled in, or discontinued within the last 30 days from a clinical trial * History of severe allergies or multiple adverse drug reactions * Have an abnormal ECG at screening visit * Have abnormal sitting blood pressure * Have an increased risk of seizures * Current suicidal ideation * Positive test for HIV, hepatitis C, or hepatitis B * Women who are breast feeding * Smoke more than 10 cigarettes per day, or equivalent * Drink more than 5 cups of coffee per day, or equivalent * Have a history of head injury * Unable to undergo a MRI * Suffer from claustrophobia