Biomarker Study in Tissue Samples From Patients With Acute Myeloid Leukemia

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from patients with acute myeloid leukemia.

OBJECTIVES: * Determine the frequency of acute myeloid leukemia (AML) that originates in CD33+ precursors or in which uncontrolled growth is restricted to CD33+ precursors. OUTLINE: Cryopreserved acute myeloid leukemia cell samples are separated from endothelial cell by fluorescent-activated cell sorting (FACS) and analyzed for X-chromosome inactivation patterns by cytogenetic/molecular analysis and/or Humara assay.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

cytogenetic analysisGENETIC

HUMARA assayOTHER

fluorescence activated cell sortingOTHER

laboratory biomarker analysisOTHER

Eligibility

Sex: FEMALEMax age: 120 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosed with acute myeloid leukemia * Known CD34+ progenitor cells * Available freshly isolated, uncultured cell samples PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Frequency of AML that originate in CD33+ or in which uncontrolled growth is restricted to CD33+ precursors

Extent of clonal hematopoiesis in small numbers of AML cells

Data from ClinicalTrials.gov

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