Satiety Response of Four Dietary Fibers

Early Phase 1CompletedNCT01233024

University of Minnesota20 enrolled

Overview

Studies have found a relationship between dietary fiber consumption and body weight regulation. This relationship may stem from enhanced satiety through fermentation of certain fibers in the large intestine. The objective of this study is to determine and compare satiety ratings, changes in food intake, and gastrointestinal effects for four fibers: fructooligosaccharide, inulin, soluble corn fiber, and resistant starch.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Healthy

Interventions

ControlDIETARY_SUPPLEMENT

Dinner bar fortified with 0g fiber; breakfast bar fortified with 0g dietary fiber.

Soluble corn fiberDIETARY_SUPPLEMENT

Dinner bar fortified with 12g fiber; breakfast bar fortified with 11g dietary fiber.

Resistant starchDIETARY_SUPPLEMENT

Dinner bar fortified with 12g fiber; breakfast bar fortified with 11g dietary fiber.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy women * Age 18-40 years * Nonsmoking * Not taking weight loss medications * Non-dieting (weight has not changed more than 11 pounds over three months) * BMI between 18.5 and 29 * Spoken and written English literacy Exclusion Criteria: * Do not regularly consume breakfast * Food allergies to wheat, soy, peanut, or dairy * BMI less than 25 or greater than 29 upon admission to study * Cancer diagnosis in past 5 years * History of heart disease, kidney disease, diabetes, or eating disorder * History of ulcerative colitis, Crohn's disease, or any other gastrointestinal condition * History of drug or alcohol abuse in past 6 months * Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication * Concurrent or recent (within 30 days) intervention study participation * Pregnant or lactating * Irregular menstrual cycle * Vegetarians * People who eat more than approximately 15 grams of fiber per day

Locations (1)

University of Minnesota

Saint Paul, Minnesota, United States

Outcomes

Primary Outcomes

Satiety response using visual analogue scales

Satiety response will be measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).

Time frame: 0, 15, 30, 45, 60, 90, 120, 180 minutes postprandially

Secondary Outcomes

Food intake

Time frame: 180 minutes postprandially and over 24 hours

Breath hydrogen response

Time frame: 0 and 180 minutes

Gastrointestinal tolerance using visual analogue scales (VAS)

Subjective ratings of bloating, stool consistency, and flatulence will be measured using VAS. A stool count will also be recorded.

Time frame: 24 hours

Data from ClinicalTrials.gov

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