Bosutinib In Subjects With Renal Impairment

Inclusion Criteria: * Males and females, aged 18 to 65. * Adequate hepatic function. * Documented creatinine clearance by Cockroft-Gault formula indicative of the respective level of renal impairment: Severe renal impairment (CrCl \<30 mL/min/1.73m2), moderate renal impairment (30 ≤ CrCl ≤50 mL/min/1.73m2), mild renal impairment (50 \< CrCl≤80 mL/min/1.73m2) and normal renal function (CrCl \>80 mL/min/1.73m2). Exclusion Criteria: * Use of any investigational drug or biologic within 4 weeks prior to the screening visit of during the screening period. * Ongoing treatment with Digoxin or strong CYP3A4 inhibitors or inducers. * Uncontrolled hypertension (for renally impaired subjects only).