Association of Apolipoprotein B-48 Level and Large arterY Atherosclerotic iSchemic Stroke(ABYSS)

Inclusion Criteria: Large artery atherosclerotic ischemic stroke group(LAA group) * Age over 20 years * Patients with symptomatic stenosis in the eligible vessels(the middle cerebral artery, anterior cerebral artery, or internal carotid artery) as assessed by MRA or CTA corresponding to the acute ischemic stroke * Patients without the occlusion of corresponding artery by MRA or CTA * The fasting and postprandial serum Apo B-48 level can be assessed within 72 hours after the symptom onset of ischemic stroke Small vessel occlusive ischemic stroke group (SVO group) * Age over 20 years * Patients with acute ischemic stroke of basal ganglia, internal capsule, or corona radiata * Patients without both symptomatic and asymptomatic arterial occlusion or stenosis by MRA or CTA * Patients without a history of systemic atherosclerosis(for example, acute myocardial infarction, angina, peripheral arterial disease, aortic aneurysm) * The fasting and postprandial serum Apo B-48 level can be assessed within 72 hours after the symptom onset of ischemic stroke Exclusion Criteria: both LAA group and SVO group * Patients with cardioembolic ischemic stroke * Patients treated with lipid lowering agents or steroid within the previous 30 dsys * Patients with severe liver disease (AST \>100 or ALT \>100) at the time of randomization * Patients with endocrine disease except diabetes mellitus at the time of randomization (for example, thyroid disease, adrenal disease) * Patients with severe renal disease (serum creatinine \>2.0mg/dl)at the time of randomization * chronic alcoholics or drug user * Patients with infection at the time of randomization * Patients, in the opinion of the investigator, unlikely to comply with the clinical study or unsuitable for the any other disease or reason * Informed consent has not been obtained