Confocal Laser Endomicroscopy in Patients With Eosinophilic Esophagitis

University of Erlangen-Nürnberg Medical School45 enrolled

Overview

Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution. Various studies have addressed the potential of endomicroscopy for the in vivo diagnosis of esophageal squamous cell carcinoma, Barrett´s esophagus and esophageal adenocarcinoma. Currently, there is only one case report from our group who noted the utility of endomicroscopy for the in vivo diagnosis of eosinophilic esophagitis. The purpose of this study is to determine whether endomicroscopy is effective for the in vivo diagnosis of eosinophilic esophagitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Eosinophilic Esophagitis

Interventions

Confocal laser endomicroscopyDEVICE

Confocal laser endomicroscopy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent * Age 18-85 years * Ability of subjects to understand character and individual consequences of clinical trial * Subjects undergoing EGD Exclusion Criteria: * Inability to provide written informed consent * Severe Coagulopathy (Prothrombin time \< 50% of control, Partial thromboplastin time \> 50 s) * Impaired renal function (Creatinine \> 1.2 mg/dl) * Pregnancy or breast feeding * Active gastrointestinal bleeding * Known allergy to fluorescein, acriflavin or cresyl violet * Residing in institutions (e.g. prison)

Outcomes

Primary Outcomes

Effectiveness of endomicroscopy for the in vivo diagnosis of eosinophilic esophagitis

Time frame: November 2010 - November 2012

Secondary Outcomes

Differentiation of mucosal alterations in patients with eosinophilic esophagitis compared to patients with gastroesophageal reflux disease.