Effects of Aerobic Training in End Stage Renal Disease Patients

Federal University of Juiz de Fora28 enrolled

Overview

The investigators raised the hypothesis that exercise training would be associated with improvement in exercise tolerance and VO2 kinetics in hemodialysis patients.

End-stage renal disease (ESRD) is associated with several hemodynamic and peripheral muscle abnormalities which could slow the kinetics of O2 uptake(VO2)and diminished tolerance to incremental exercise. Although previous studies have shown that aerobic training is able to accelerate VO2 kinetics in several disease populations, little is known if these positive findings are also applicable to hemodialysis patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Kidney Failure, Chronic

Interventions

Exercise trainingOTHER

Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: The sample included end stage renal disease patients undergoing hemodialysis, three times per week totaling 12h weekly, for at least 6 months in the Nephrology Unit at the University Hospital of the Federal University of Juiz de Fora, State of Minas Gerais, Brazil. No patient had been involved in any kind of exercise training in the preceding 6 months Exclusion Criteria: * unstable angina; * uncontrolled arrhythmia; * uncompensated heart failure; * uncontrolled hypertension (systolic blood pressure ≥ 200 mmHg and/or diastolic blood pressure ≥ 120 mmHg); * diabetes mellitus; * severe respiratory diseases; * acute infection; * severe renal osteodystrophy; * neurological or musculoskeletal disturbances

Locations (1)

Federal University of Juiz de Fora-Núcleo Interdisciplinar de Estudos e Pesquisas em Nefrologia (NIEPEN)

Juiz de Fora, Minas Gerais, Brazil

Outcomes

Primary Outcomes

Effects of aerobic training during hemodialysis on exercise tolerance and VO2 kinetics in end stage renal disease patients

Before and after the intervention or control periods, the participants were submitted to an incremental work rate test and, two days apart, to a constant work rate test to the limit of tolerance.

Time frame: 3 months

Data from ClinicalTrials.gov

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