The purpose of this study is to objectively quantify liver fat content (LFC) by Magnetic Resonant Imaging (MRI) prior to major liver surgery, and to investigate its association with post-operative complications.
Lack of agreement exists among expert pathologists in the standard histological assessment of hepatic steatosis on biopsy. The impact of different grades of steatosis on postoperative complications after major liver resection remains controversial.
Study Type
OBSERVATIONAL
Enrollment
84
Conventional pre-operative MRI
Hepatectomy of \>= 3 liver segments
University Hospital Zurich, Department of Interventional and Diagnostic Radiology
Zurich, Canton of Zurich, Switzerland
University Hospital Zurich, Department of Visceral and Transplant Surgery, Swiss Hepato-Pancreato-Biliary (HPB) Center
Zurich, Canton of Zurich, Switzerland
Percentage of Liver Fat Content on MRI in Patients With Serious Post-operative Complications (Clavien-Dindo Grade ≥IV)
Liver fat content, measured by MRI, uses the in-phase/out-of-phase imaging calculated in terms of fat signal fraction (FSF). The Clavien-Dindo Classification of Surgical Complications: Grade I: Any deviation from the normal postoperative course without the need for treatment. Grade II: Requiring pharmacological treatment with drugs. Grade III: Requiring surgical, endoscopic or radiological intervention. Grade IV: Life-threatening complication requiring IC/ICU-management. Grade V: Death of a patient
Time frame: December 2010
Post-operative Alanine Transaminase (ALT) Levels
Alanine Transaminase is commonly measured clinically as a part of a diagnostic evaluation of hepatocellular injury, to determine liver health.
Time frame: December 2010
Intra-operative Blood Loss
Intra-operative blood loss was defined according to the total volume of blood loss from the beginning until the end of the operation.
Time frame: December 2010
Operative Time
The operation duration was measured according to the total minutes from the beginning of the operation until the end.
Time frame: December 2010
Intensive Care Unit (ICU) Stay
The Intensive Care Unit (ICU) stay was calculated according to the total number of days the patients were managed in the ICU. This included also multiple ICU admissions.
Time frame: December 2010
Hospital Stay
The patient hospital stay was calculated according to the total number of days the patient was hospitalized.
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Time frame: December 2010
Cost
The total in-hospital costs were calculated for each patient in Euros.
Time frame: December 2010
Type of Post-operative Complications
There are several different types of post-operative complications associated with liver surgery, such as liver failure, multi-organ failure, bleeding, bile leak, and sepsis.
Time frame: December 2010