Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia

Mahidol University40 enrolled

Overview

The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.

Thoracotomy causes severe pain to the patients. Continuous thoracic epidural is a gold standard for postoperative pain. However, it needs skill. There are many alternatives such as spinal morphine, intercostal nerve block, cryoalangesia or interpleural block.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Solitary Mass Lung Diseases

Interventions

spinal morphine 0.3 mgDRUG

spinal morphine 0.3 mg

spinal morphine 0.2 mgDRUG

spinal morphine 0.2 mg

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 year and \< 70 year * Patient ASA physical status I-III. * Scheduled for thoracotomy with lobectomy. * Can operate a patient-controlled analgesia (PCA) device. Exclusion Criteria: * Known hypersensitivity to morphine or pethidine * History of bleeding tendency. * Known case of infection at the back * Patient refuse for spinal anesthesia * History of cerebrovascular disease. * Scheduled for video-assisted thoracoscopic lobectomy. * Need mechanical ventilatory support during postoperative period

Locations (1)

Faculty of Medicine, Siriraj Hospital

Bangkok, Thailand

Outcomes

Primary Outcomes

pethidine requirement

Total pethidine requirement during 48 hours postoperative

Time frame: 48 hours

Data from ClinicalTrials.gov

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