The purpose of this study is to determine if MR Perfusion Imaging is non-inferior to coronary angiography with measurement of Fractional Flow Reserve (FFR) in guiding management of patients with stable chest pain. * All patients will undergo an MR Perfusion Imaging test. * Further management will be guided by the result of the cardiac MRI in half of the patients (chosen by random). * The other half will undergo coronary angiography with measurement of FFR. The result of this test alone will guide their further management. The result of the initial MR Perfusion test will not be available to the treating doctors of this group. * All patients will receive optimal medical therapy (OMT) * All patients will undergo follow-up to find out if they have any relevant heart related events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
915
Coronary revascularization guided by MR perfusion imaging
Coronary revascularization guided by invasive angiography and FFR
King's College
London, United Kingdom
Occurence of major adverse cardiac events (MACE)
Composite of all cause death, myocardial infarction and repeat revascularisation.
Time frame: 1year
Individual MACE
individual components as defined above
Time frame: 1 year
Other adverse events
need for revascularization after initial treatment within 1 year
Time frame: 1 year
Course of symptoms (angina, breathlessness)
CCS class, NYHA class
Time frame: 1 year
Cost comparison
Costs related to MR- and FFR-guided selection for revascularisation
Time frame: 1 year
changes in LV volumes and function
Time frame: 1 year
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