A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers

University of Southern Denmark50 enrolled

Overview

The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in Caucasian with the known single nucleotide polymorphisms A270S in OCT2.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Metformin Organic Cation Transporter 2 Polymorphism,Single Nucleotide

Interventions

MetforminDRUG

A single dose study with one tablet of metformin 500 mg, time frame 24 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Written consent * rs316019 genotyped * Age 18-65 years old Exclusion Criteria: * Daily medication * Alcohol abuse * Pregnancy * Breastfeeding

Locations (1)

Institute of Public Health, Clinical Pharmacology, University of Southern Denmark

Odense, Denmark

Outcomes

Primary Outcomes

Renal clearance of metformin

Time frame: 24 Hours

Data from ClinicalTrials.gov

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