Title: The acute effect of narghile smoking on endothelial Function, and exhaled breath condensate (EBC) and pulmonary function tests in healthy volunteers. Objectives: To evaluate the acute effect of one cession of narghile smoking on endothelial Function, airway inflammation as assessed by exhaled breath condensate (EBC) in healthy volunteers. Design: Prospective study evaluating these parameters before and after 30 minutes of Narghile smoking. The changes in inflammatory parameters pre and post smoking will be evaluated blindly. Sample size: 50 participants Participant selection: Adults subjects who smoke Narghile . Intervention: Each subject will undergo evaluation including a respiratory questionnaire, endothelial Function , pulmonary function tests , exhaled breath condensate (EBC) and carboxy- hemoglobin levels . All measurements will be evaluated before and after one cession of 30 minutes narghile smoking.
Study Type
OBSERVATIONAL
Enrollment
62
No Other intervention will be used
Rambam Medical Center
Haifa, Israel
PRE - Endothelial Function as assessed by EndoPAT2000
as assessed by EndoPAT2000. a pulse-oxymeter that asseses the endothelial function
Time frame: baseline (before smoking narghile)
POST - Endothelial Function as assessed by EndoPAT2000
as assessed by EndoPAT2000. a pulse-oxymeter that asseses the endothelial function
Time frame: after 30 minutes of smoking narghile
carboxy- hemoglobin
Blood Test
Time frame: before and immediatly after 30 min of smoking
heart rate
Heart Beats count
Time frame: before and immediatly after 30 min of smoking
Visual Analog Score 1-10 (1=bad 10=good)
Questionnaire
Time frame: before and immediatly after 30 min of smoking
Respiratory Rate
Time frame: before and immediatly after 30 min of smoking
Spirometry
Koko spirometry system
Time frame: before and immediatly after 30 min of smoking
Eosinophils Count
Blood Test
Time frame: before and immediatly after 30 min of smoking
Blood Pressure
Regular Blood Pressure assesment
Time frame: before and immediatly after 30 min of smoking
Exhaled Breath Condensate
R-tubes test
Time frame: before and immediatly after 30 min of smoking
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