Efficacy of Cultivated Corneal Epithelial Stem Cell for Ocular Surface Reconstruction

Mahidol University19 enrolled

Overview

The purpose of this study is to elucidate the appropriate condition of developing cultivated corneal epithelial graft and evaluate the surgical outcome of transplantation of the cultivated corneal epithelial stem cell in the patients.

Ocular surface damage caused by severe ocular surface diseases, particularly thermal and chemical burn or Stevens-Johnson syndrome result in corneal epithelial defect, corneal vascularization, corneal conjunctivalization and loss of transparency. Corneal limbal stem cell transplantation has been demonstrated to improve the outcome of ocular surface reconstruction. However, the conventional management of allograft limbal transplantation generally has unsatisfactory outcome because of high risk of rejection and requires long-life immunosuppressive medications.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Severe Ocular Surface Damage Limbal Deficiency

Interventions

Cultivated limbal transplantationPROCEDURE

Cultivated corneal epithelial stem cell transplantation. Autograft, Living related allograft, and Cadaveric allograft

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Unilateral/Bilateral limbal stem cell deficiency proved by specific clinical features and impression cytology result Exclusion Criteria: * Age under 18 * Active ocular infection, Severe dry eye, Uncontrolled glaucoma * Immunocompromised host * Pregnancy

Locations (1)

Pinnita Prabhasawat, MD

Bangkok, Thailand

Outcomes

Primary Outcomes

Ocular surface status (signs of limbal deficiency and immunopathological markers)

Time frame: Three years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.