Experimental Denture Pastes

Raphael Freitas de Souza36 enrolled

Overview

This trial aims to evaluate the efficacy of three experimental dentifrices to remove denture biofilm. Complete denture wearers will be instructed to brush their dentures with a specific toothbrush and four compositions: (1) A proprietary denture-specific paste (active comparator); (2) 0.2% chloramine T; (3) 1.0% chloramine T; (4) 0.01% fluorosurfactant. Each treatment will be used for periods of 7 days, and participants will be randomized to use them according to one of four sequences.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Dental Plaque Denture Stomatitis Oral Candidiasis Oral Hygiene

Interventions

DentifriceOTHER

Dentifrices (4 formulations) used as auxiliary agents for brushing complete dentures.

Eligibility

Sex: ALLMin age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Completely edentulous * Good general health * Patients requesting new complete dentures (volunteers will receive the interventions before new complete dentures) * Regular wearing of the same maxillary and mandibular complete dentures for 3 to 10 years * Both denture bases and artificial teeth should be composed by acrylic resin Exclusion Criteria: * Unsatisfactory complete dentures in use (i.e. with poor fitting, relining or fractures) * Absence of deposits of biofilm at baseline

Locations (1)

Ribeirão Preto Dental School

Ribeirão Preto, São Paulo, Brazil

Outcomes

Primary Outcomes

Denture plaque coverage area (%)

Relation between stained area and total surface area on the internal surface of maxillary complete dentures.

Time frame: 7 days

Data from ClinicalTrials.gov

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