The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients

Inclusion Criteria: * Must report cognitive difficulties of 3 or higher on a 0-10 scale * Must provide informed consent * Be able to read English * Have a primary diagnosis of cancer * Be able to swallow medication * Women of child-bearing potential must not be pregnant or become pregnant during the 6 week study * Agree not to take NSAIDs during the 6 week intervention period * Be scheduled to receive at least 2 additional cycles of oral or IV chemotherapy over the 42-day study period. * Must have the approval of their treating physician to begin the exercise program and receive the ibuprofen * Must be over 18 years of age Exclusion Criteria: * Currently taking a consistent dosage of a NSAID at least 3 days a week for the last 3 months that is over 400mg daily * Have an allergy to ibuprofen * Be identified as in active or maintenance stage of exercise behavior as assessed by the single-item exercise stages of change short form * have physical limitations that contraindicate participation in sub-maximal physiological fitness testing or a low to moderate home-based walking and progressive resistance program * have a history of peptic ulcer disease within the last 12 months * Diagnosed with a neurodegenerative disease * Had a myocardial infraction within the past 6 months * Patients with a neutropenic episode during the first cycle of chemotherapy or at high risk for a neutropenic episode during future chemotherapy cycles at the treating physicians discretion * Have confirmed metastatic disease to the central nervous system * Have been hospitalized for a major psychiatric illness within the last 5 years