Use of Lidocaine in Rapid Sequence Induction

University of Athens76 enrolled

Overview

Lidocaine has been shown to blunt the cardiovascular response to endotracheal intubation. The incidence of hypertension, tachycardia and dysrhythmias due to laryngoscopy may be increased in patients that receive rapid sequence induction and intubation, where opioids are spared and intravenous anesthetic agents are not titrated step by step. Our hypothesis was that lidocaine when administered intravenously in patients who undergo rapid sequence induction may not only blunt the hemodynamic response to intubation, but may also increase the anesthetic depth (as assessed by BIS), thus further reducing the possibility of hypertension, arrhythmias and also awareness.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

TRIPLE

Enrollment

Conditions

Hemodynamic Response

Interventions

LidocaineDRUG

lidocaine 1.5 mg/kg intravenously

PlaceboDRUG

normal saline

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * reason for rapid sequence induction (emergency, reflux), * ASA I-II, * no antihypertensive drugs, * no antiarrhythmic drugs Exclusion Criteria :

Locations (1)

Aretaieio Hospital, University of Athens

Athens, Attica, Greece

Outcomes

Primary Outcomes

BIS changes after lidocaine administration in rapid sequence induction

Time frame: change from baseline in BIS values during 10 minutes

Secondary Outcomes

change in blood pressure

Time frame: change from baseline in blood pressure during 10 minutes

change in Heart rate

Time frame: change from baseline in heart rate durng 10 minutes

Data from ClinicalTrials.gov

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