Combined Nutrient Intake and Muscle Protein Synthesis

Maastricht University Medical Center48 enrolled

Overview

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Aging

Interventions

proteinOTHER

20g protein

protein and carbohydrateOTHER

20g protein and 20g carbohydrate

protein and leucineOTHER

20g protein, 2.5g leucine

Eligibility

Sex: MALEMin age: 70 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * males * 70-85 years or 18-30 years * BMI \< 30 Exclusion Criteria: * Type II diabetes * All co morbidities interacting with mobility and muscle metabolism of the lower limbs * Use of anticoagulants * Patients suffering from Phenylketonuria * Participation in any regular exercise programme

Locations (1)

Universiteit Maastricht, Bewegingswetenschappen

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

Muscle protein synthesis

Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).

Time frame: 6 h postprandial period

Data from ClinicalTrials.gov

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