ProSat - Long Term Effect of Probiotics on Satiety

University of Copenhagen66 enrolled

Overview

The aim of the ProSat study is to examine the effects of a probiotic capsule containing Lb. Casei on subjective appetite sensation, ad libitum energy intake, and appetite hormone response in a single meal test and to determine whether the acute effects persist after daily supplementation of the probiotic capsule.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Obesity Appetite Regulation

Interventions

ProbioticDIETARY_SUPPLEMENT

Parallel, randomized, controlled 2 arms study.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * Normal to slight overweight (BMI: 22-28 kg/m2) * 20-45 years of age Exclusion Criteria: * Smoking * Daily medicine use (oral contraceptives excluded) * Use of pre- and probiotic supplements and foods * Blood donation 3 months prior to the study * Hb \< 7,5mmol/l * Chronic illnesses such as hyperlipidemia, diabetes inflammatory diseases * Pregnancy or breastfeeding * Elite athletes (\>10 hours hard exercise/week) * Vegetarians

Locations (1)

University of Copenhagen, Department of Human Nutrition

Frederiksberg, DK, Denmark

Outcomes

Primary Outcomes

Glucose, insulin, GLP-1, GLP-2, CCK, PYY, PP, ghrelin, amylin, LPS, TNF-alfa, CRP, fibrinogen.

Time frame: June 2011

Secondary Outcomes

Subjective appetite measurements, spontaneous food intake.

Time frame: June 2011

Data from ClinicalTrials.gov

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