To Compare Ofloxacin With Azitromycin for Pelvic Inflammatory Disease (PID) Treatment

Guilan University of Medical Sciences100 enrolled

Overview

Objective: To compare two oral treatments: Ofloxacin + Metronidazole, and Azitromycin +Metronidazole in outpatients with Pelvic Inflammatory Disease. Materials and Methods: Two hundred patients divided to two groups( A , B). Group A (treated by Ofloxacin 400 mg. + Metronidazole 500mg) and Group B (a single dose of oral Azitromicine 1gr + Metronidazole 500mg) for 10 days, were compared in terms of side effects and efficacy

Two hundred patients divided to two groups( A , B). Group A (treated by Ofloxacin 400 mg. + Metronidazole 500mg) and Group B (a single dose of oral Azitromicine 1gr + Metronidazole 500mg) for 10 days, were compared in terms of side effects and efficacy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Pelvic Inflammatory Disease

Interventions

Ofloxacin group A, Azitromycin group BDRUG

Group A (treated by Ofloxacin 400 mg. + Metronidazole 500mg) and Group B (a single dose of oral Azitromicine 1gr + Metronidazole 500mg) for 10 days, were compared in terms of side effects and efficacy.

azitromycinDRUG

azitromicin vs ofluxacin

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria:Eligibility criteria were having three out of five following symptoms: a-lower abdominal pain, b-vaginal discharges, c- adnexal tenderness, d-cervical motion tenderness (CMT), e-cervisitis. \- Exclusion Criteria:Excluding criteria were as follows: a-unmarried women, b-pregnant women, c-women with infection during menstruation, d- history of abortion or miscarriage during the last month, e-underlying diseases such as diabetes, f-used antibiotics in the last month, or allergy to the antibiotics used in the study, g-history of Pelvic Inflammatory Disease within the last year, and h- suspicion of being multi partner. \-

Locations (1)

Alzahra Maternity Hospital

Rasht, Gilan Province, Iran

Outcomes

Primary Outcomes

to compare two oral antibiotic protocols in terms of side effects and efficacy.

side effects- and efficacy

Time frame: Jan 2010- Aug 2010

Secondary Outcomes

single oral dose of Azitromicine could be the drug of choice in the outpatient treatment of Pelvic Inflammatory Disease

compliance and cost

Time frame: Jan 2010- Aug 2010

Data from ClinicalTrials.gov

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