Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies

Inclusion Criteria: * 18 years old or greater * Malignancy scheduled to receive etoposide and carboplatin therapy * Eastern Cooperative Oncology Group (ECOG) performance of 0 or 1 * Adequate bone marrow, liver, renal function and coagulation status * Informed consent * Agree to use birth control through 28 days of last treatment dose * Pregnancy test for women of child-bearing potential * No available standard therapy Exclusion Criteria: * Allergy to the the study treatment drugs * Unstable current medical condition * Presence or history of injury to the urinary tract * Active infection * Major surgery within 4 weeks prior to treatment * Minor surgery within 2 weeks prior to treatment * Current acute steroid therapy or taper * Currently pregnant or nursing * Substance abuse or condition that may interfere with participation * Received other investigational drugs within 30 days * Within 4 weeks of their last chemotherapy