Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy

Tianjin Medical University Cancer Institute and Hospital40 enrolled

Overview

The purpose of this study is to determine the safety and efficacy of the side-to-side stapled intrathoracic esophagogastric anastomosis in Ivor-Lewis Oesophagectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Esophageal Cancer

Interventions

side-to-side stapled esophagogastric anastomosisPROCEDURE

20 patients of distal esophageal cancer receive side-to-side stapled esophagogastric anastomosis in Ivor-Lewis oesophagectomy

circular-stapled esophagogastric anastomosisPROCEDURE

20 patients of distal esophageal cancer receive circular-stapled esophagogastric anastomosis in Ivor-Lewis oesophagectomy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cancer of the distal esophagus or gastroesophageal junction confirmed by biopsy (squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma) clinical stage I, II, or III. * Received no previous treatment for esophageal cancer * Adequate bone marrow, liver and kidney function * Patients must be able to understand the nature consent of the study and give written informed consent. Exclusion Criteria: * Age \< 18 years * History of significant heart disease * Inoperable on the basis of co-existent medical problems

Locations (1)

Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy

Tianjin, Tianjin Municipality, China

Outcomes

Primary Outcomes

Long and short outcome related with anastomoses

Include anastomotic leakage,anastomotic stricture,regurgitation,heartburn, dumping syndrome and anastomoses diameter.

Time frame: 3 year

Secondary Outcomes

Quality of life and function outcomes

Time frame: 3 year

Data from ClinicalTrials.gov

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