Randomized Double Blinded Study Evaluating CACICOL20 Efficiency Versus Placebo Corneal Chronic Ulcers Healing

Inclusion Criteria: * Patients with non-infectious, corneal chronic ulcer, painful or not ,whose depth does not exceed the superficial stroma. * Resistance of corneal pathology to standard treatment: eye drops to promote healing, tear substitutes, anti-inflammatory drugs, cyclosporin. * Patients previously treated for the corneal pathology, assessed ineffective or Insufficiently effective by the investigator * Patients using wetting gel or eye drops without conservator during the inclusion * Anti-inflammatory local treatments must be stopped for at least 8 days. * No contact lenses or lenses must be removed for at least 8 days. * Age of inclusion ≥ 18 years. * Written and signed informed consent from patient. * Realization of a preliminary medical examination. * Covers by social insurance Exclusion Criteria: * Ulcers deeper than the superficial stroma, perforated ulcers or pre-perforated * Corneal abscess * Infectious and progressive ulcerative keratitis * Patients receiving anti-inflammatory eye drops or steroid with cyclosporine treatment (in this case, possibility of inclusion in the clinical protocol after a Case "wash-out of 8 days) * Patients on long-term eye drops containing preservatives and can not be stopped or replaced by an equivalent without preservatives * Patients on systemic anti-inflammatory, anti-allergic, psychotropic or antibiotics therapies, modified since less than 10 days or likely to be on short-term * Wearing contact lenses if patient has not been stopped at least eight days before the start of the protocol * ocular surgery within the last 3 months * patient already included in another clinical trial with an investigational product * Pregnant patients or breastfeeding * Person under a legal protection measure, under guardianship * Unable to follow up medical examinations for geographical, social or psychological reasons * Not cover by social insurance.