A Magnetic Resonance Imaging Study of Patients With Cervical Spondylosis

Assistance Publique - Hôpitaux de Paris40 enrolled

Overview

This study aims at evaluating spinal cord structure using diffusion tensor imaging in patients with cervical spondylosis.

Diffusion tensor imaging (DTI) of the cervical spinal cord will be performed in patients with cervical spondylosis with varying degrees of symptoms and in healthy control subjects. Fibre tracking of main spinal tracts will be performed. Regions of interest will also be identified. Diffusion parameters will be extracted. This will allow quantification of degree of damage in of the spinal cord. The findings will be related to motor function measures and comprehensive clinical tests of sensory and motor function.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Cervical Spondylosis

Interventions

DTI - Diffusor Tensor ImagingDEVICE

Radiology intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-70 years old * Sufficiently cooperative * Cognitively understands study and implications * Signed informed consent * Symptomatic cervical spondylosis Exclusion Criteria: * MRI contraindications (e.g., pacemaker, metal implants, claustrophobia) * Previous pathology that would impact behavioural measures * Anxiety and poor cooperation * Previous neurological condition * Pregnancy

Locations (1)

Cochin Hospital, Radiology B

Paris, Île-de-France Region, France

Outcomes

Primary Outcomes

DTI parameters in cervical spinal cord

Time frame: 3 weeks

Secondary Outcomes

Clinical data, i.e., Muscle testing, sensory testing, reflexes, spasticity, and Motor function (dexterity test), grip strength

Clinical data, i.e., Muscle testing, sensory testing, reflexes, spasticity Motor function (dexterity test), grip strength

Time frame: 3 weeks

Data from ClinicalTrials.gov

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