COVADIS Pilot Trial: COseal in Ventricular Assist DevIceS

Inclusion criteria (CoSeal group): 1. Written informed consent obtained from the subject prior to participation in the study 2. At least 18 years of age 3. Subjects with indication for LVAD implantation, meeting the requirements for LVAD implantation. Patients for whom the investigator anticipates LVAD removal not earlier than 6 weeks after LVAD implantation. Inclusion criteria (CoSeal control group): 1. Written informed consent obtained from the subject prior to participation in the study 2. At least 18 years of age 3. Subjects who had a LVAD for more than 6 weeks. Exclusion criteria (CoSeal group): 1. Concomitant use of any other anti-adhesion product 2. Immune system disorders, immuno-deficiencies or immuno-suppression 3. Known hypersensitivity to components of the study product 4. Patients concurrently participating in another clinical trial for adhesion prevention or sealing evaluation and having received such an investigational drug or device within the previous 30 days 5. Patients who were previously subject to another LVAD implantation/explantation 6. Pregnant or breast-feeding women. Exclusion criteria (Co Seal control group): 1. Known use of any other anti-adhesion product during VAD implantation 2. Immune system disorders, immuno-deficiencies or immuno-suppression 3. Patients concurrently participating in another clinical trial for adhesion prevention or sealing evaluation and having received such an investigational drug or device within the previous 30 days 4. Patients who were previously subject to another LVAD implantation/explantation 5. Pregnant or breast-feeding women.