Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis

University of Aarhus50 enrolled

Overview

Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with alcoholic hepatitis. The liver might play an important role in this stress-catabolism by increasing the production of urea during the inflammatory process. The purpose of this study is to examine the regulation of urea synthesis in patients with alcoholic hepatitis and to study the effect of the anti-inflammatory drugs prednisolone and pentoxifylline on this regulation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Alcoholic Hepatitis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Alcoholic hepatitis (alcohol intake (\> 40g/day in 6 months), bilirubin \> 80 μmol/l) Exclusion Criteria: * Severe bacterial infections * Other chronical inflammatory diseases * Cancer * Other catabolic diseases * Treatment with prednisolone or pentoxifylline within the last 8 weeks

Locations (1)

Department of Medicine V, Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Functional Hepatic Nitrogen Clearance

Time frame: At inclusion, after approximately 3 month and if severe alcoholic hepatitis also after 14 days medical treatment

Secondary Outcomes

Clinical and biochemical measures of inflammation

Time frame: At inclusion, after approximately 3 month and if severe alcoholic hepatitis also after 14 days medical treatment

Data from ClinicalTrials.gov

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