A Study of RO4905417 in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery

Inclusion Criteria: * Adult patients, \> 18 and \> 85 years of age * Patients undergoing primary multi-vessel CABG with at least one saphenous vein graft. with or without cardiopulmonary bypass * Body mass index (BMI) \</= 35 kg/m2 Exclusion Criteria: * Participation in previous studies evaluating RO4905417 * Positive for HIV, receiving antiretroviral drugs, or immuno-suppressed * Acute infection at screening or active chronic infection within 3 months prior to CABG surgery * Patients undergoing emergency cardiac surgery for an immediately life-threatening condition * Patients undergoing concomitant valve surgery * History of CABG (only patients without prior CABG surgery will be admitted to the study) * Left ventricular ejection fraction \< 20% * History of transient ischemic attack or stroke within the 12 weeks prior to the CABG procedure * Significant renal or liver impairment * Malignancy diagnosed within the previous 5 years (except for successfully resected basal cell cancer)