A Study of Fostamatinib in Subjects With Impaired Kidney Function

Inclusion Criteria: * Males or females (non child bearing potential) greater than or equal to 18 years of age with suitable veins for cannulation or repeated venipuncture and with a weight of at least 50 kg (110 lbs) and body mass index (BMI) between 18 and 40 kg/m2, inclusive * Stable renal impairment with following creatinine clearance (CLCR): Stage 1 - End Stage Renal Disease (ESRD) \< 15 mL/min (requiring dialysis); Stage 2 - Mild renal impairment ≥ 50 to \< 80 mL/min; Moderate renal impairment ≥ 30 to \<50 mL/min; and severe renal impairment 15 to \< 30 mL/min * Healthy subjects with normal renal function must have good health based on medical history, physical examination , echocardiogram and clinical laboratory evaluations including creatinine clearance \>80 ml/min" * Negative screen for Human Immunodeficiency Virus and negative results for serum hepatitis B surface antigen and hepatitis C antibody Exclusion Criteria: * Subjects who have received any medications known to chronically alter drug absorption or elimination processes within 30 days of the first dose administration * Absolute neutrophil count less than 1600/mm3 or 1.6 x 109 L. * Healthy subjects only: Subjects who have received any prescribed systemic or topical medication within 14 days of the first dose administration * Subjects with a history of multiple drug allergies or with a known allergy to the drug class of fostamatinib * In the opinion of the Investigator, any evidence of additional severe or uncontrolled systemic disease (eg, currently unstable or uncompensated hepatic, cardiovascular, or respiratory disease) or laboratory finding