Skin Testing and ELISPOT Assay in Patients With a History of Non-Immediate Reactions to Cephalosporins

Chulalongkorn University28 enrolled

Overview

This study aims to compare the results of skin testing and ELISPOT assay in patients with a history of non-immediate reactions to cephalosporins

Patients with a history of non-immediate reactions to cephalosporins will be tested by patch test and/or intradermal test. Peripheral blood mononuclear cells will be collected to analyzed cytokine secretions by ELISPOT assay

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cephalosporin Allergy Non-immediate Drug Reactions

Interventions

Skin tests and ELISPOT assayPROCEDURE

Patch test and/or intradermal test will be performed in patients as well as cytokine secretions from PBMCs will be analyzed by ELISPOT assay

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with a history of non-immediate hypersensitivity reactions to cephalosporins 2. At least 18 years of age Exclusion Criteria: 1. Suffering from severe systemic disease/ in bad health 2. Being pregnant 3. Patients with a history of immediate reactions to cephalosporin

Locations (1)

Faculty of Medicine, Chulalongkorn University

Bangkok, Thailand

Outcomes

Primary Outcomes

The skin testing results of Cephalosporin skin test compared to ELISPOT assay

Time frame: 1 year

Secondary Outcomes

The result of cross reactivity between Cephalosporins and other Betalactams determined by skin testing and ELISPOT assay

Time frame: 1 year

Data from ClinicalTrials.gov

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