Expression of Optic Atrophy Type 1 (OPA1) Protein in Lung Adenocarcinoma

China Medical University Hospital100 enrolled

Overview

Optic atrophy type 1(OPA1) is a nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion. Mitochondria fusion is associated with process of apoptosis. . OPA1 plays an important role in the mitochondrial bioenergetics and mitochondrial networks. The changes in mitochondrial shape and mitochondrial bioenergetics may be cause of the disease. In this study, we investigate the expression of OPA1 in lung adenocarcinoma (LADC) cells and tissue.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Lung Adenocarcinoma

Eligibility

Sex: ALLMin age: 25 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * We will collect paraffin blocked resected lung tissue samples from stage I\~IIIa non-small cell lung cancer patients (age, 40\~80 years old) who received lobectomy of the affected lung. Exclusion Criteria: * History of uremia, other malignant disease, and liver cirrhosis * History of pneumonia and pulmonary tuberculosis * History of long period of medications.

Locations (1)

Fang Hsin Yuan

Taichung, Taiwan

RECRUITING

Data from ClinicalTrials.gov

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