A Study of Relative Bioavailability and Food Effect Study of Cobimetinib in Healthy Participants

Inclusion Criteria * Within body mass index range 18.5 to 29.9 kilograms per meter square (kg/m\^2) * In good health, determined by no clinically significant findings from medical history, 12-lead electrocardiogram (ECG) and vital signs * Clinical laboratory evaluations within the reference range for the test laboratory * Negative test for selected drugs of abuse at Screening and at each Check-in * Negative hepatitis panel and anti-hepatitis C virus and negative human immunodeficiency virus (HIV) antibody screens * Healthy males and females of non-child-bearing potential or who agree to use effective contraception Exclusion Criteria * Significant history or clinical manifestation of any significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, or psychiatric disorder * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance * History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs except that appendectomy, hernia repair, and cholecystectomy will be allowed * History or presence of an abnormal ECG * History of alcoholism or drug addiction prior to study start * Use of any tobacco-containing or nicotine-containing products prior to study start * Participation in any other investigational study drug trial in which receipt of an investigational study drug occurred within 28 days or 5 half-lives, whichever is longer, prior to study start * Use of any prescription medications/products, including proton pump inhibitors, within 14 days prior to study start * Poor peripheral venous access * Any acute or chronic condition that would limit the participant's ability to complete and/or participate in this clinical study * Female participant is pregnant, lactating, or breastfeeding * Predisposing factors to retinal vein occlusion (RVO)