Parkinson's Disease, Diagnostic Observations (PADDO)

Radboud University Medical Center150 enrolled

Overview

Background: Parkinson's Disease and the Atypical Parkinsonian Disorder (like Multiple System Atrophy, Progressive Supranuclear Palsy, Corticobasal Degeneration, Lewy Body Dementia) are disease entities with partly common symptomatology. Especially very early in the course of disease, the differentiation between both disease entities can be challenging, even for specialists in the field of movement disorder. However, the establishment of a correct diagnosis is very important for adequate patientcounseling, treatment and the correct inclusion of patients in research trials. Ancillary diagnostic investigations are looked upon to aid in this diagnostic dilemma. Objective: To investigate the value of ancillary diagnostic investigations, more specific MRI, analysis of cerebrospinal fluids and a second opinion in a specialized movement disorder centre, to differentiate Parkinson's disease and the Atypical Parkisonisonian disorder.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Parkinson's Disease Atypical Parkinsonism

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hypokinetic rigid syndrome * Disease duration of maximum 36 months Exclusion Criteria: * Probable diagnosis of PD without any red flags * Probable diagnosis MSA * Probable diagnosis PSP * Diagnosis CBD * Diagnosis DLB * Probable diagnosis Vascular Parkinsonism * Other neurodegenerative disease than parkinsonism * A prior history of brain surgery * Instable comorbidity

Outcomes

Primary Outcomes

percentage of correct diagnosis for each of the specified ancillary investigations

Percentage of correct diagnosis for each of the specified ancillary investigations to differentiate between either PD or atypical parkinsonism

Time frame: 36 months

Secondary Outcomes

Percentage of correct diagnosis for each of the specified ancillary investigations

Percentage of correct diagnosis for each of the specified ancillary investigations(MRI, CSF analysis, and second opinion) to differentiate between the specific diagnosis (PD, MSA, PSP, CBD, LBD, VaP)