Study to Assess the Tolerability, Safety and Efficacy of an Adapted Gut Cleansing Solution in Routine Colon Cleansing Prior to Colonoscopies

Inclusion Criteria: * The subject's written informed consent must be obtained prior to inclusion. * Male or female ambulatory subjects aged between 40 to 75 years undergoing a complete colonoscopy for colon cancer screening. * No history of significant gastrointestinal diseases, including gastrointestinal obstruction and perforation or acute symptoms requiring a colonoscopy procedure. * Willing to undergo a colonoscopy for colon cancer screening. * Willing, able and competent to complete the entire procedure and to comply with study instructions. * Females of childbearing potential must employ an adequate method of contraception. Exclusion Criteria: * History of gastric emptying disorders * History of ileus, toxic megacolon, gastrointestinal obstruction and colonic perforation * History of Phenylketonuria * Known Glucose-6-phosphate dehydrogenase deficiency * Known hypersensitivity to macrogol 3350, sodium sulphate or ascorbic acid/ sodium ascorbate * History of colonic resection * Requirement for permanent medication and associated stable serum concentrations (e.g. neuroleptic drugs) * Presence of congestive heart failure (NYHA III + IV) * Acute life-threatening cardiovascular disease * Documented history of severe renal insufficiency * Application of any unlicensed medication within the previous 3 months or participation in any other research study in the last 3 months * Females who are pregnant, nursing or planning a pregnancy. Females of child bearing potential not using reliable methods of contraception * Subjects who the investigator feels would not be compliant with the requirements of the trial