Single and Multiple Dose Asian Bridging Study

Key Inclusion Criteria: * Normal healthy adult males and females (age 20-45 years) * Body Mass Index greater than or equal to 18 and less than or equal to 29 at the time of screening * Japanese and Chinese subjects must be born in their respective countries of origin and have parents and grandparents of Japanese or Chinese descent, respectively * Japanese subjects must have lived outside of Japan for no more than 5 years; Chinese subjects must have lived outside of China for no more than 10 years * In addition to mainland China, Chinese subjects may be from Taiwan, Hong Kong, or Mongolia * Japanese and Chinese subjects must not have significantly changes their lifestyle with regard to diet; i.e., their diet must not have significantly changed since leaving China or Japan * Platelet count between 150,000 and 300,000/mm3 Key Exclusion Criteria: * Evidence of clinically significant cardiovascular, hepatic, gastrointestinal, renal, respiratory, endocrine, hematologic, neurologic, or psychiatric disease or abnormalities or a known history of any gastrointestinal surgery that could impact the PK of the study drug * Evidence of organ dysfunction or any clinically significant deviation from normal in their medical history, e.g., history of splenectomy * History of venous or arterial thrombotic disease or other hypercoagulable state * Hemoglobin level less than 12.0 g/dL