The aim of the present study was to investigate the effects of Gynostemma Pentaphyllum tea on insulin sensitivity in drug-naïve type 2 diabetic patients.
In Vietnam, traditional herbal medicines have played a major role in the management of diabetes for centuries. Gynostemma Pentaphyllum (GP) Makino (Family Cucurbitaceae) is a perennial creeping herb growing wild in the mountainous regions of Vietnam, China and some other Asian countries and was widely used in Southeast Asian countries as an herbal medicine and being beneficial for the prevention and treatment of diabetes. We have previously published the evidences that GP tea possessed anti-diabetic effect with good safety data in newly diagnosed T2D patients, and had effect on insulin sensitivity. In addition extract of GP had been shown to reduce both hyperglycemia and hyperlipidemia in diabetic Zucker Fatty rats. So the present study was to investigate the effects of Gynostemma Pentaphyllum tea in insulin sensitivity in type 2 diabetic patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
16
6g/day per oral, twice a day in 10 weeks, 30 minutes before breakfast and dinner
6g/day per oral, twice a day in 10 weeks, 30 minutes before breakfast and dinner
National Institute of Gerontology, HMU
Hanoi, Vietnam
National Institute of Gerontology
Hanoi, Vietnam
Fating plasma glucose, Steady state plasma glucose in Somatostatin-Insulin-Glucose Infusion Test
All subjects participated in Somatostatin-Insulin-Glucose Infusion Test (SIGIT), lasting 150 minutes, performed at 8am after an 8-10h overnight fast with only tap water allowed ad libitum. Somatostatin was used to suppress endogenous insulin release, thereby allowing estimation of sensitivity to exogenously administered insulin by measuring blood glucose value at 90, 120 and 150 minute of the test (SIGIT mean).
Time frame: 10 weeks
Liver enzymes (ALT, AST)
Time frame: 10 weeks
Kidney function (S-creatinine, S-BUN)
Time frame: 10 weeks
Plasma lipids (TG, Cholesterol, HDL-, LDL-)
Time frame: 10 weeks
Blood pressure
Time frame: 10 weeks
Body weight (BMI, hip-waist ratio)
Time frame: 10 weeks
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