Gut protein metabolism that could be influenced by protein supply is involved in the regulation of several physiological functions such as gut barrier function and represents a major contribution in the whole-body protein turnover. Intracellular pathways implicated in the transduction of amino acids effects remained unknown in the human gut. Thus, the aim of the present project is to evaluate and to understand the effects of amino acids (glutamine, leucine) on gut protein metabolism (synthesis and degradation) in young healthy humans.
Study Type
OBSERVATIONAL
Enrollment
36
Centre d'Investigation Clinique - Hôpital charles Nicolle
Rouen, Seine maritime, France
assessment of intestinal protein synthesis stimulation by Leucine or glutamine in duodenal biopsy
Time frame: 18 months
Assessment of involved signaling pathways
Time frame: 18 months
Assessment of intestinal proteolysis
Time frame: 18 months
Assessment of protein synthesis rate in intestinal mitochondria
Time frame: 18 months
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