A Comparison of the Effectiveness of Seroquel XR and Seroquel XR Plus Lithium in Patients With Acute Bipolar Mania: An Open-label, Randomized, Parallel Groups, Rater-blinded, 4 Week, Multicenter, Comparative,Study

Inclusion Criteria: * Female and/or male inpatients or outpatients, aged over 18 years and under 65 years * Documented clinical diagnosis meeting the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria * YMRS total score =20 at enrollment and randomization (Day 1) Patients had a history of at least one manic episode that required hospitalization and/or treatment with a mood stabilizer or antipsychotic. * Female patients must have a negative urine human chorionic gonadotropin (HCG) test at enrolment and must be using a reliable method of birth control, ie, barrier method, oral contraceptive, implant, dermal contraception, long-term injectable contraceptive Exclusion Criteria: * Pregnancy or lactation Meeting the criteria for any other (than bipolar disorder) DSM-IV Axis I diagnosis, concomitant organic mental disorder or mental retardation * Patients who, in the opinion of the investigator, pose an imminent risk of suicide or a danger to self or others * Administration of a depot antipsychotic injection within one dosing interval (for the depot) before randomization/baseline * Known intolerance or hypersensitivity to, or lack of response to previous treatment with quetiapine fumarate or lithium