Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy

Inclusion Criteria: * Ability to provide written informed consent and comply with study assessments for the full duration of the study * Subjects of either gender, Age greater than or equal to 50 years * Best corrected visual acuity in the study eye between 20/25 and 20/320 * Subfoveal choroidal neovascularization, secondary to age related macular degeneration * Total lesion size less than 4 disc diameters * Any subretinal hemorrhage must comprise no more than 50% of total lesion size. * Clear ocular media and adequate papillary dilation to permit good quality stereoscopic fundus photography * Ability to return for all study visits Exclusion Criteria: * Pregnancy (positive pregnancy test)or lactation * Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel,an IUD,or contraceptive hormone implant or patch. * Patients with any form of prior eye treatment for AMD including: Photodynamic Therapy, anti-VEGF Therapy, Laser, Vitreoretinal surgery * Had ocular surgery within the past 60 days in study eye * Concurrent use of more than two therapies for glaucoma * Uncontrolled glaucoma in the study eye(defined as intraocular pressure\>30mm Hg despite treatment with anti-glaucoma medication) * Concurrent use of systemic anti-VEGF agents * Has active infection in the study eye(s) * Inability to obtain photographs to document CNV * Has received investigational therapy within 60 days prior to study entry * Patients with significantly compromised visual acuity in the study eye due to concomitant ocular conditions. * Has other conditions the investigator considers to be sound reasons for exclusion(e.g., lack of motivation, history of poor compliance, concomitant illnesses, personality disorder, mental condition, drug abuse, use of neuroleptics, physical or social condition predicting difficulty in long-term follow-up). * Has an allergy to sodium fluorescein dye * Inability to comply with study or follow-up procedures