Long-term Caloric Restriction and Cellular Aging Markers

University of California, San Francisco71 enrolled

Overview

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aging

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Calorie restricting group: Self-reported caloric restriction for at least two years * Calorie restriction group: BMI below 23 * Normal eating control: Normal eating (no history of caloric restriction) for two years * Normal eating control: BMI below 30 * Obese comparison group: BMI above 30 * Obese comparison group: Normal eating (no history of caloric restriction) for two years Exclusion Criteria: * Regular smoker for the past six months

Locations (1)

University of California

San Francisco, California, United States

Outcomes

Primary Outcomes

Telomere Length

This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).

Time frame: One day

Data from ClinicalTrials.gov

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