The Study of Polycystic Ovary Syndrome (PCOS) and Questionnaire

Taipei Medical University WanFang Hospital306 enrolled

Overview

Polycystic ovary syndrome (PCOS) is an extremely common disorder in women of reproductive age. Diagnosis of PCOS is principally based on clinical and physical findings. Diagnostic criteria and PCOS definitions used by clinicians and researchers are almost as heterogeneous as the syndrome. This first part of study is determine whether genetic polymorphisms influence hormonal and metabolic characteristics in Taiwanese patients with PCOS and controls. Furthermore, women with PCOS were reported with high risk of cardiovascular disease, the investigators planned to calculate the difference of carotid intima-media thickness (IMT) and B-type natriuretic peptide (BNP) between women with PCOS and normal control to determine the premature atherosclerosis of women with PCOS.

Study Type

OBSERVATIONAL

Enrollment

306

Conditions

Polycystic Ovary Syndrome

Eligibility

Sex: FEMALEMin age: 15 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women at reproductive age * women with PCOS and women without PCOS Exclusion Criteria: * young women who had their menarche less than 3 years * women older than 45 years old, Amenorrhea of menopause, hyperglycemia, hyperthyroidism, hypothyroidism, heart failure, lung failure, renal failure, anemia, dystrophy, gonitis

Locations (1)

Taipei Medical University-WanFang Hospital

Outcomes

Primary Outcomes

Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome.

To evaluate the contribution to glucose intolerance and metabolic syndrome of obesity combined with the diagnostic criteria of polycystic ovary syndrome (PCOS).

Time frame: Prospectively study in University teaching hospital from 31 August 2010 to 31 August 2011.