Driving Simulator Performance After Intake of Zopiclone Sleeping Pills

Inclusion Criteria: * Male * Caucasian ethnicity * Age 25-35 years * Possession of a driver's licence for at least five years Exclusion Criteria: * Score ≥ 2 on the modified Apfel-scale to assess risk for motion sickness(\*) * History of driving under the influence of alcohol and/or illicit substances * History or presence of alcohol or illicit drug abuse * Former abnormal reaction to any hypnotic drug * History of strong averse reactions to blood sampling procedures * Regular (daily) intake of any prescribed drug, or intake of grapefruit juice or herbal remedies that can influence the metabolism of zopiclone (e.g. St John's wort) * History of severe allergic reactions, or significant mental, cardiovascular, renal or hepatic disorder, or other significant disease as judged by the investigators * Detection of any drugs of abuse on pre-session urine drug screening (\*)Modified Apfel-criteria for prediction of postoperative nausea/vomiting: 1. Smoker? yes 0, no 1 2. History of nausea and/or vomiting following surgery, dental treatment, injections or similar procedures? yes 0, no 1 3. History of car sickness after 10 years of age? yes 0, no 1 A score of two or more points excludes participation.