Quantification of Human Adipogenesis

Brigham and Women's Hospital20 enrolled

Overview

This pilot study is using a novel technology to measure the rate of turnover of new fat cells. Analysis of volunteer samples is ongoing, however the study is currently not enrolling new volunteers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Interventions

15N-Thymidine, 2H-WaterBIOLOGICAL

Stable isotope 15N-thymidine, infused IV (15mg/hour) for 72 hours (phase 1 pilot). Stable isotope 2H-water, ingested by mouth once per day for 3 days (phase 1 pilot) or 28 days (phase 2 pilot).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18-49 years. * Healthy. Exclusion Criteria: * Significant chronic medical illness. * Illicit substance or alcohol abuse. * Body mass index \> 27 kg/meters squared. * Underweight (BMI \< 20 kg/m2). * History of keloid formation (excessive scarring). * Pregnant.

Locations (1)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Quantifying human adipogenesis-counting the number of new fat cells.

Time frame: 4 weeks-7 months

Data from ClinicalTrials.gov

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