Peri-operative Expression Analysis of Pancreatic Stone Protein in a Surgical Study Population

University of Zurich30 enrolled

Overview

The purpose of this study is to analyze the peri-operative expression of pancreatic stone protein and pancreatitis-associated protein in surgical patients following major abdominal surgery by blood samples.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Patients Undergoing Major Abdominal Surgery

Interventions

Analysis of PSP and PAP from venous blood samplesOTHER

to analyse the peri-operative expression of pancreatic stone protein in surgical patients following major abdominal surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion criteria: - \>= 18 years * abdominal major surgery * need for post-operative ICU care Exclusion criteria: - \<18 years \- patients who do not agree the written informed consent

Locations (1)

Department of Visceral and Transplantation Surgery

Zurich, CH/Zürich, Switzerland

Outcomes

Primary Outcomes

Diagnosed Infections according to the Systemic Inflammatory Response System (SIRS) Criteria of the german interdisciplinary Association of Intensive and Emergency Medicine

Time frame: 2 years

Secondary Outcomes

Intensive Care Unit (ICU) stay in days

Time frame: 2 years

hospital stay in days

Time frame: 2 years

postoperative complications according to the "Clavien-Dindo Classification" System

Time frame: 2 years

hospital costs

Time frame: 2 years

comparisons to other known infectious parameters: c-reactive protein (CRP), procalcitonin (PCT), Interleukin 6 (IL-6), Tumor Necrosis Factor Alpha (TNF-alpha), Leucocytes

Time frame: 2 years

Bacteriaemia in the blood

Time frame: 2 years

Platelets in the blood

Time frame: 2 years

Data from ClinicalTrials.gov

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