Mycoplasma pneumoniae, an important pathogen of community acquired pneumonia,are becoming more and more resistant to macrolide. The study aim is to optimize anti-infection therapy.
Mycoplasma pneumoniae was one of important atypical pathogens of community acquired pneumonia. As lack of cell wall, β-lactam medicines were invalid, however, macrolides, tetracyclines and quinolones were effective. But from 2001, many countries reported macrolide- resistant Mycoplasma pneumoniae. Typically, erythromycin was first-line antibiotic medicine. With the resistance increasing, Mycoplasm pneumonia treatment will become more and more difficult. Thus, optimization of Mycoplasm pneumonia antibiotic therapy is very important.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
208
0.4 Qd for 7days
cefuroxime 1.5 bid for 7 days plus azithromycin 0.5 qd for 7 days
Capital Medical University affiliated Beijing Chaoyang Hospital, Beijing Respiratory Medicine Insititute
Beijing, Beijing Municipality, China
Time to resolution of fever (defined as the period from start of study-drug to relief of fever)
usually duration of fever is about one to two weeks
Time frame: one month
Time to resolution of fever (defined as the period from onset to relief of fever)
usually duration of fever is about one to two weeks
Time frame: one month
Time to resolution of respiratory symptoms(defined as the period from start of study-drug to relief of symptoms)
Time frame: one year
Time to resolution of respiratory symptoms(defined as the period from onset to relief of symptoms)
Time frame: one year
Proportion of antibiotics change
Time frame: one year
Duration of antibiotics
Time frame: one year
Proportion of resolution of fever after antibiotics therapy for 24 hours
Time frame: one year
Proportion of resolution of fever after antibiotics therapy for 72 hours
Time frame: one year
Antibiotic-related adverse reaction
Time frame: one year
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