The purpose of this study is to evaluate the efficacy and safety of Meditoxin® in the treatment of Essential blepharospasm.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
110
2 times, Intra-muscular injection, Maximum dosage total 60U
Sevrance Hospital
Seoul, South Korea
Seoul St.Mary Hospital
Seoul, South Korea
Chung-Ang Univesity Yongsan Hospital
Seoul, South Korea
the change rate of Jankovic Rating Scale score
To evaluate the change of JRS(Jankovic Rating Scale) score at 4 weeks post treatment based on baseline( 0 week).
Time frame: 4weeks
the change rate of Jankovic Rating Scale scale
To evaluate the change of JRS(Jankovic Rating Scale) at retreatment point or 16 weeks post treatment based on Baseline(0 week).
Time frame: 0 week, 16weeks(or retreatment point)
the change rate of Blepharospasm Disability Index
To evaluate the change of Blepharospasm Disalbility Index at 4weeks, 8weeks, 16weeks(or retreatment point) post treatment.
Time frame: 0week, 4weeks, 8weeks, 16weeks(or retreatment point)
Global assessment about the improvement
To evaluate the Global assessment about the improvement at 4weeks post treatment.
Time frame: 4weeks
the duration of efficacy
To evaluate the duration of efficacy
Time frame: retreatment point or 16 weeks
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