This is an observational study to evaluate the feasibility of the implementation of a personalized treatment strategy based on specific tumor marker (f.i. EGFR-mutation) in the routine clinical care setting in the Antwerp region (Belgium).
The favourable results of a number of phase III-trials with gefitinib in NSCLC patients with activating EGFR-mutations, have resulted in the licensing of gefitinib in this indication. This offers the prospect of a true personalized treatment of patients with NSCLC. Implementation of such a personalized treatment strategy is dependent both on the availability of adequate tumor samples for the EGFR-mutation analysis and on the timely reporting of the mutation analysis results. Ideally the results should be available in all patients within 2 weeks of the analysis request.
Study Type
OBSERVATIONAL
Enrollment
107
Universitair Ziekenhuis Antwerpen
Edegem, Antwerpen, Belgium
AZ Monica
Antwerp, Belgium
GZA Sint Vincentius - Sint Augustinus
Antwerp, Belgium
ZNA Middelheim - ZNA STER - ZNA Jan Palfijn
Antwerp, Belgium
testing turn around time (in days)
how long does it take to get the mutation analysis result
Time frame: up to 1 month
demographics
age, gender, tumor histology, smoking history
Time frame: baseline
correlation between pulmonary function/pulmonary antecedents and EGFR-mutation status
Time frame: baseline
correlation between family history with regards to cancer and EGFR-mutation status
Time frame: baseline
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AZ St Jozef Bornem en Willebroek
Bornem, Belgium
AZ Klina
Brasschaat, Belgium
AZ St Dimpna
Geel, Belgium
AZ St Elisabeth
Herentals, Belgium
AZ Mol
Mol, Belgium
AZ Nikolaas
Sint-Niklaas, Belgium
...and 1 more locations