To determine whether oral or intravenous ibuprofen has a better or same efficacy and tolerance in closure of patent ductus arteriosis in extremely-low-birth-weight preterm infants.
To determine whether oral or intravenous ibuprofen has a better or same efficacy and tolerance in closure of patent ductus arteriosis in extremely-low-birth-weight preterm infants.Seventy ELBW preterm infants with patent ductus arteriosis will be enrolled in this prospective-randomized study. Patients will receive either intravenous or oral ibuprofen at an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 h. One of the following echocardiographic criteria of a duct size \>1.5 mm, a left atrium-to-aorta ratio \>1.5, left-to-right shunting of blood, end diastolic reversal of blood flow in the aorta, or poor cardiac function in addition signs of patent ductus arteriosis determined the need of ibuprofen treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
70
oral or iv ibuprofen in 10, 5 and 5 mg/kg/day with 24 hr intervals
Zekai Tahir Burak Maternity Teaching Hospital
Ankara, Turkey (Türkiye)
Efficacy and Safety of Oral Versus Intravenous Ibuprofen... ID: STO5336205575
To compare the closure rate of patent ductus arteriosus after intravenous or oral ibuprofen treatment
Time frame: 6 months
Efficacy and Safety of Oral Versus Intravenous Ibuprofen
Evaluation of renal tolerance and complications
Time frame: Results will be identified in 6 months
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