The primary purpose of the trial is to evaluate coagulation activator markers in patients with pre eclampsia compared to control (normal pregnancy) and to correlate these markers with the severity of the pathology.
100 pre-eclamptic patients will be compared to 200 control patients (100 control matched on gestational age at inclusion and 100 control matched on delivery mode (section). Blood and urine samples will be collected at PE diagnosis, delivery and post partum. Two axes will be considered: 1. Thrombography, or kinetic measurement of thrombin generation, by studying the coagulant profile according to Hemker's method in CAT System (Calibrated Automated Thrombogram) and by thromboelastogram in ROTEM technique (delocalized coagulation analyzer), in parallel to specific activation markers (thrombin-antithrombin complex, fibrin monomers). 2. The balance of prostacyclin/thromboxane A2 by using ELISA method for urine samples and genotype-phenotype correlation (Polymorphism of prostacyclin-synthetase's promoter CYP8A1).
Study Type
OBSERVATIONAL
Enrollment
300
University Hospital of Lille
Lille, Nord, France
Endogenous thrombin potential
comparison of Endogenous thrombin potential between patients with Preclampsia (PE) (at the moment of the diagnosis of PE) compared to control (at the same gestational age)
Time frame: at preeclampsia diagnosis
genotype-phenotype correlation (Polymorphism of prostacyclin-synthetase promoter CYP8A1
Time frame: at pre eclampsia diagnosis
In preeclampsia group : correlation between biological markers and severity of the disease
correlation of endogenous thrombin potential and rotem results with : presence or absence of severe preeclampsia presence or absence of HELLP Syndrome presence or absence of IUGR presence or absence of eclampsia
Time frame: at the diagnosis of preeclampsia
evolution of endogenous thrombin potential in women with preeclampsia
Study of the evolution of endogenous thrombin potential during the time period of diagnosis of preeclampsia to day 2 of the post partum.
Time frame: between the diagnosis of preeclampsia and day 2 of the post partum period
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